The altar of Saint Ignatius is especially noteworthy, showcasing a sumptuous relief altarpiece portraying Saint Ignatius in a moment of ecstasy as he receives the rule for the Society of Jesus from God.
In the lower section, the four known continents of the time are represented: Africa with a lion, Asia with a dromedary, Europe with the papal crown, and America with a quiver of arrows. Oceania is missing, as it had not yet been discovered. The entire altar is adorned with inlays of marble and precious stones; the altar frontal, unique in its kind, depicts a variety of exotic birds.
The first chapel on the left as you enter is dedicated to Saint Anne, with frescoes by Luigi Borremans; on the right is the Chapel of Our Lady of Mount Carmel, featuring a beautiful altar frontal made of precious stones. The main altar, dedicated to Saint Agatha, is surmounted by a large painting by Agostino Scilla depicting the martyrdom of the saint from Catania. On either side of the presbytery are two paintings by Vincenzo Roggeri.